| Isis Highway | |
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| Length | 166 km |
| General direction | North-South |
| From | Bourbong Street, Bundaberg, Queensland |
| via | Childers, Biggenden |
| To |  Burnett Highway, Ban Ban Springs, Queensland |
| Allocation | Bundaberg - Childers:
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| Major Junctions |  Bruce Highway |
The Isis Highway is a state highway in southern Queensland, Australia. The highway is relatively short, and runs for 142 kilometres in a north-east direction from its junction with the Burnett Highway at Ban Ban Springs to Bundaberg. The Isis Highway links the cattle farming districts of the North Burnett with the sugar producing Bundaberg and Fraser Coast region. The highway takes its name from the Isis River, which flows between Maryborough and Childers. The highway also passes through a significant amount of the Isis Shire Local Government Area, of which Childers is the administrative centre. The Isis Highway is signed as State Route 52 between Ban Ban Springs and Childers, and State Route 3 from Childers to Bundaberg.
