Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells. IRS-1, for example, is an IRS protein which contains a PTB-domain. In addition, the insulin receptor contains a NPXpY domain. The PTB-domain binds the NPXpY domain. Thus, the insulin receptor binds IRS.
Genes
- IRS1 (see also Insulin receptor substrate 1)
- IRS2 (see also Insulin receptor substrate 2)
- IRS3L
- IRS4
References
- van der Geer P, Wiley S, Pawson T (1999). "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene 18 (20): 3071-5. doi:10.1038/sj.onc.1202879. PMID 10340378.
