Hombre, the Spanish word for "man" and sometimes used informally in English, may refer to:
- Hombre, a 1961 novel by Elmore Leonard
- Hombre, a 1967 motion picture based on the novel starring Paul Newman and directed by Martin Ritt
- Hombre, a Spanish comics series by Antonio Segura and José Ortiz
- The Hombres, a Memphis, Tennessee rock group who had a hit in 1967 with "Let It Out (Let It All Hang Out)"
- L'Hombre (or, in 17th Century Spanish orthography, Ombre), a card game of Spanish origin
- Hombre chipset for Commodore-Amiga computers.
- Hombres Motorcycle Club A Red and Gold Motorcycle club based in Washington State.
