The title Guy I may refer to:
- Guy I of Jebail, of the Embriaco family
- Guy I de la Roche (1205-1263), Duke of Athens
- Guy I of Montlhéry (d. 1095)
- Guy I of Ponthieu (d. 1100)
- Guy I of Spoleto (d. 860)
- Guy I, Count of Blois (d. 1342)
- Guy I of Albon
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