Dr. No may refer to:
- Dr. No (novel), the 1958 James Bond novel by Ian Fleming
- Dr. No (film), the first James Bond film, starring Sean Connery
- Dr. No (soundtrack), the soundtrack for the movie of the same name.
- Julius No, the title character and primary villain of the novel and film
- Ron Paul, a member of the U.S. House of Representatives whose medical degree and frequent dissenting votes earned him the nickname
- Ian Paisley, a member of the Northern Ireland Assembly, whose speeches of old, commonly objecting strongly to the Anglo-Irish Agreement, earned him the nickname
- Joel Wachs, former member of the Los Angeles City Council
