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CD55 molecule, decay accelerating factor for complement (Cromer blood group)
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| Identifiers | |
| Symbol | CD55 |
| Alt. Symbols | DAF |
| Entrez | 1604 |
| HUGO | 2665 |
| OMIM | 125240 |
| RefSeq | NM_000574 |
| UniProt | P08174 |
| Other data | |
| Locus | Chr. 1 q32 |
Decay accelerating factor (CD55) is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex. This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.
Pathology
DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; however, this deficiency is not the cause of PNH.
See also
External links
- MeSH Decay-Accelerating+Factor
- Cromer blood group system at BGMUT, Blood Group Antigen Gene Mutation Database at NCBI, NIH
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| Activators | CLA: C3-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin |
| Enzymes | C: C1Q/C1R/C1S - C4 (A) - C2 - CLA: C3 - C5 (C5a) - L: MASP1 - MASP2 - A: Factor B - Factor D |
| Inhibitors | CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H |
| Complement receptors | CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a) |
