The Death Inducing Signaling Complex or DISC is a multi-protein complex formed by members of the death receptor family of apoptosis-inducing cellular receptors. The typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase-8. It transduces a downstream signal cascade resulting in apoptosis.
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| STAT | STAT1 - STAT2 - STAT3 - STAT4 - STAT5 - STAT6 |
| Interferon regulatory factors | IRF1 - IRF2 - IRF3 - IRF6 |
| Growth factor receptor-bound protein | GRB2 - GRB7 - GRB10 |
| other | 14-3-3 (YWHAE, YWHAZ) - Caveolin - Cortactin - Death Inducing Signaling Complex - Paxillin - Myd88 - PIAS - SMAD - SOCS - TRAF |
