Daniel Rutherford Haldane (27 March 1824 – 12 April 1887) was a prominent Scottish physician, who became president of the Royal College of Physicians of Edinburgh. His parents were minister James Alexander Haldane, and his second wife Margaret Rutherford, a daughter of Professor Daniel Rutherford. On 17 September 1856 he married Charlotte Elizabeth Lowthorpe (died 11 September 1908) daughter of James Lowthorpe of Welton Hall.
- Charlotte Wilhelmina Lowthorpe Haldane
- <unknown female> (1857-?)
- Margaret Harriet Rutherford Haldane
- Edith Millicent Haldane, (1861-1862)
- Alice Mary Haldane, (1861-?)
- General Sir James Aylmer Lowthorpe Haldane (1862-)
- Anne Evelyn Haldane, (1864-?) married Charles John Haldane Hogg, son of Sir Frederick Russell Hogg.
