DES may mean:
- Data Encryption Standard, a deprecated cryptographic block cipher that falls to brute force attacks due to its short 56-bit key
- Diethylstilbestrol, a synthetic estrogen developed to supplement a woman's natural estrogen production
- Delivered Ex Ship, an Incoterm
- Deep Ecliptic Survey, an astronomy project to find Kuiper belt objects
- Department of Education and Science, a former department in the United Kingdom government
- Detached eddy simulation, a turbulence model used in computational fluid dynamics
- Discrete event simulation, a simulation that models a system by examining its changes as discrete events
- Drug-eluting stent, a device placed in coronary arteries to treat or prevent heart attacks
- DirectShow Editing Services, a Microsoft DirectShow API.
- Discrete event system, a system with state changes driven by discrete events
- Diffuse esophageal spasm, a condition resulting from a disorder of the esophagus
- The Dark Energy Survey, a proposed survey of part of the Southern sky to determine cosmology parameters
- the Dietary Energy Supply. a measure of how many calories are available per person in each country
- Dysequilibrium syndrome, former name for VLDLR-associated cerebellar hypoplasia
DES or Des may also be:
- The IATA airport code for Desroches Airport
- A shortened form of the names Desmond and Desiree
- Discipline Economiche e Sociali (Economics and Social Sciences); a degree course in economics held at Bocconi University.
- The musical note D♭, in German nomenclature
