Clarksville is the name of some places in the United States of America:
- Clarksville, Alabama
- Clarksville, Arkansas
- Clarksville, California
- Clarksville, Delaware
- Clarksville, Florida
- Clarksville, Idaho
- Clarksville, Illinois
- Clarksville, Indiana
- Clarksville, Iowa
- Clarksville, Maryland
- Clarksville, Michigan
- Clarksville, Missouri
- Clarksville, New Hampshire
- Clarksville, New Jersey
- Clarksville, Albany County, New York
- Clarksville, Allegany County, New York
- Clarksville, Ohio
- Clarksville, Oklahoma
- Clarksville, Oregon
- Clarksville, Pennsylvania
- Clarksville, Tennessee (best-known city with this name)
- "Last Train to Clarksville", #1 song by The Monkees, referring to Clarksville, Tennessee
- Clarksville, Texas
- Clarksville Historic District, Austin, Texas
- Clarksville, Virginia
