Californication may refer to:
- Californication (album), an album by the Red Hot Chili Peppers
- "Californication (song)", the title track and fourth single from the album.
- Californication (portmanteau), an expression that refers to the influx of Californians into various western states in the U.S.
- Californication (TV series), a US television series
- "Californication" (Californication episode), the pilot episode of the series
