CRC may refer to:
- California Rehabilitation Center, a state prison in the USA.
- Cambridge Regional College F.C., a semi-professional football club in England
- Camp Red Cloud, a US Army Camp in Uijeongbu, South Korea
- Canada Research Chair
- Cancer Research Campaign
- Capablanca random chess, a 10x8 chess variant
- Capital Research Center
- Cartier Railway (AAR reporting mark: CRC), a railway that operates in the Canadian province of Québec
- China Resources Company (華潤)
- Civil Rights Commission
- Colorectal cancer
- Committee on the Rights of the Child
- Communications Research Centre, an agency of Department of Industry (Canada)
- Communications Residential College (CRC), a dormitory at Northwestern University
- The ICAO airline designator for Conair Aviation, Canada
- Convention on the Rights of the Child
- Cooperative Research Centre, a type of hybrid academic/industry research body existing in Australia
- Corrosion Reaction Consultants, manufacturers of CRC lubricant (similar to WD-40)
- Costa Rican colón, the official currency of Costa Rica
- Cote R, a grading scheme for CEGEP students in Quebec, Canada.
- CRC Press, publisher, originally the Chemical Rubber Company
In computer science:
- Class-Responsibility-Collaboration cards, popularized by Rebecca Wirfs-Brock, and Ward Cunningham of WikiWikiWeb fame
- Cyclic redundancy check, a type of hash function used to produce a checksum, in order to detect errors in transmission or storage
In religion:
- Canadian Reformed Churches
- Central Rabbinical Congress, a Haredi group.
- Chassidic Rabbinical College
- Chicago Rabbinical Council
- Christian Reformed Church
- CRC Churches International, a Pentecostal Protestant Christian denomination located primarily in Australasia.
