CBL is a three letter acronym that could mean:
- Calculator-Based Laboratory
- Cambuslang railway station – see UK railway stations - C
- Canadian Baseball League (defunct)
- Cannabicyclol
- Carl Barks Library
- CBL & Associates Properties
- CBL, the ticker symbol for CBL & Associates Properties, Inc.
- CBL Data Recovery Technologies (company) a data recovery technology company
- CBL-FM, a CBC Radio Two radio station in Toronto, Ontario.
- The Cbl gene found in mammals
- CBC Radio One in Toronto had the call sign CBL for much of the period when it was on the AM band (1937-1999). Its FM call sign is CBLA.
- Centraal Bureau Levensmiddelenhandel
- Central Bank of Liberia
- Chesapeake Biological Laboratory
- Chester Beatty Library
- Chinese Basketball League
- China Baseball League
- Citrus Belt League
- Class-based language
- Composite Blocking List
- Computer Based Learning
- Conemaugh and Black Lick Railroad (AAR reporting marks CBL)
- Continental Basketball Association (current)
- Continental Basketball League (defunct)
- Cross-body lead, a dance move
- Cross-border leasing
