Brenner might refer to:
- The Brenner Pass, one of the major passes through the Alps, linking Italy and Austria
- Brenner, Italy, in the province of Bolzano-Bozen
- Brenner Base Tunnel railway tunnel through the base of the Brenner massiv.
- Brenner (crater)
- Brenner tumour
- Givat Brenner and Brenner Regional Council, a kibbutz and a regional council in Israel.
- Crick, Brenner et al. experiment
People with the surname Brenner
- David Brenner
- Ernst Brenner (1856–1911), Swiss politician
- Helmut Brenner, an Austrian ethnomusicologist
- Hoby Brenner
- John Brenner, an American shot putter
- John Lewis Brenner
- Joshua Ilika Brenner
- Lenni Brenner
- Malcolm Brenner
- Sydney Brenner, a biologist
- Victor David Brenner, an American sculptor and designer of the Lincoln Wheat Ears Cent
- Vytas Brenner
- Yosef Haim Brenner, a Hebrew language author
- Yul Brenner, a Russian-French-American actor
- Zeke Brenner
