The three-letter acronym BFF can refer to:
- The band Ben Folds Five
- The airport code for the Western Nebraska Regional Airport near Scottsbluff, Nebraska.
- The ISO 639-2 code for the Bofi language.
- The phrase "Best Friends Forever", also used as the eponym for a South Park episode, "Best Friends Forever".
- Backup File Format - an AIX binary distribution package
- Boston Film Festival


