Acid Citrate Dextrose Solution (sometimes called Anticoagulant Citrate Dextrose Solution) is a solution of citric acid, sodium citrate and dextrose in water. It is mainly used as an anticoagulant to preserve blood, it is also used during procedures such as plasmapheresis instead of heparin. Two different solutions (Solution A and B) are defined by the United States Pharmacopeia. They have the following properties:
| Total Citrate (as Citric acid, anhydrous (C6H8O7)) | 20.59 to 22.75g |
| Dextrose (C6H12O6*H2O) | 23.28g to 25.73g |
| Sodium (Na) | 4.90g to 5.42g |
| Total Citrate (as Citric acid, anhydrous (C6H8O7)) | 12.37 to 13.67g |
| Dextrose (C6H12O6*H2O) | 13.96 to 15.44g |
| Sodium (Na) | 2.94 to 3.25g |
To make use:
| A | B | |
| Citric Acid, anhydrous (C6H8O7) | 7.3g | 4.4 |
| Sodium Citrate, dihydrate | 22.0g | 13.2 |
| Dextrose, monohydrate (C6H12O6*H2O) | 24.5g | 14.7 |
| Water for Injection to make | 1000 mL | 1000 mL |
Dissolve the ingredients and mix. Filter until clear.
References
United States Pharmacopeia 26, 2002, pp 158.
