Benzodiazepine

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(BDZ) Any of the group of drugs with ANTICONVULSANT, ANXIOLYTIC, hypnotic and muscle-relaxant properties. They act at the GABA receptor complex type A, where they bind as agonists to a specific benzodiazepine binding site.

Here, they facilitate GABAergic inhibitory neurotransmission. Examples of the class include DIAZEPAM (valium) and nitrazepam (mogadon). Benzodiazepines have a variety of indications, including INSOMNIA, termination of SEIZURES, ANXIETY and PANIC disorders. Though very safe drugs, particularly in overdose, there is considerable risk of TOLERANCE and physical and psychological DEPENDENCE.

IAN C.REID

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