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Dictionary of Biological Psychology
Requiring the presence of free OXYGEN. Adrenoceptor potency and location | SUBTYPE | RELATIVE POTENCY | LOCATION | alpha 1A | NA>adrenaline | HIPPOCAMPUS, PONS, MEDULLA OBLONGATA, SPINAL CORD | alpha 1B | NA=adrenaline | CEREBRAL CORTEX, THALAMUS, HYPOTHALAMUS, CEREBELLUM | alpha 1D | NA=adrenaline | HEART | alpha 2A | adrenaline>NA | LOCUS COERULEUS, AMYGDALA, hippocampus, thalamus | alpha 2B | adrenaline>NA | thalamus, KIDNEY | alpha 2C | adrenaline>NA | locus coeruleus, amygdala, hippocampus, thalamus, SUBSTANTIA NIGRA, STRIATUM | beta 1 | NA>adrenaline | receptors for SYMPATHETIC NERVOUS SYSTEM actions of noradrenaline; also cerebral cortex | beta 2 | adrenaline>NA | receptors in tissues for HORMONE-like actions of adrenaline and noradrenaline; also cerebellum | beta 3 | NA=adrenaline | BROWN ADIPOSE TISSUE; ADIPOSE TISSUE | beta 4 | NA>adrenaline | uncertain as yet |
Drugs acting at adrenoceptors | alpha 1 receptors: | agonists: | PHENYLEPHRINE, METHOXAMINE, CIRAZOLINE | | antagonists: | WB4101, PRAZOSIN, PHENOXYBENZAMINE, CORYNANTHINE | alpha 2 receptors: | agonists: | ALPHA-METHYL-NORADRENALINE, CLONIDINE, OXYMETAZOLINE, B-HT920, UK14,3O4 | | antagonists: | YOHIMBINE, RAUWOLSCINE, IDAZOXAN | beta receptors: | agonists: | ISOPROTERONOL, ALBUTEROL (also Called SALBUTAMOL) | | antagonists: | PROPRANOLOL, ALPRENOLOL, PINDOLOL | | (these two groups are non-selective with respect to beta receptor subtypes) | beta 1 receptors: | agonists: | DENOPAMINE, XAMOTEROL | | antagonists: | ATENOLOL, BISOPEROL | beta 2 receptors | agonists: | PROCATEROL, SULFONTEROL | | antagonists: | ICI-118,551 | beta 3 receptors: | agonists: | CL-316,243 |
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