White Fang has been adapted to film at least eleven times in seven countries: the United States, France, Germany, Italy, the United Kingdom, Spain, and Australia. Among the most widely available versions are White Fang, made in the United States and released in 1991, directed by Randal Kleiser and starring Klaus Maria Brandauer and Ethan Hawke; and White Fang II: Myth of the White Wolf, another American film released in 1994, directed by Ken Olin and starring Scott Bairstow and Alfred Molina.

There are at least two audio adaptations of White Fang. An unabridged version on cassette, read by William Hootkins, was released by Penguin Books Limited in 1998. An abridged version, read by the late actor John Ritter, was released by New Millennium Audio in 2002.