In 1955, Tender Is the Night was adapted as an hour-long television special, starring Mercedes McCambridge as Nicole Diver. In 1962, the novel was adapted as a Hollywood film by Henry King. Produced by Twentieth Century Fox Studios, the film stars Jennifer Jones, Jason Robards, Jr., Joan Fontaine, Tom Ewell, and Jill St. John and is available on video. A 1985 three-hour miniseries adaptation, starring Peter Strauss, Edward Asner, and Sean Young was directed by Robert Knight.

A ten-cassette, unabridged reading of the novel was produced by Sterling Audio out of Thorndike, Maine.

Of related interest, "Last Call: The Final Chapter of F. Scott Fitzgerald," starring Jeremy Irons and Sissy Spacek, was released as a Showtime Original Picture in 2003 and is available on video. This video depicts the last few months of Fiztgerald's life.