Guare wrote the screenplay for the film adaptation of Six Degrees of Separation, directed by Fred Shepisis The film starred Stockard Channing (who played Ouisa IN the original production), Donald Sutherland (Flan), and Will Smith (Paul). The film is available from MGM/UA Home Video, 1994.

The play was recorded in audio version for L.A. Theatre Works IN 1999. Swoosie Kurtz spoke the role of Ouisa, Alan AIda the role of Flan, and Chuma Hunter-Gault the role of Paul.