A film version of The Portrait of a Lady was directed by Jane Campion and released in 1996. It stars Nicole Kidman as Isabel, John Malkovich as Gilbert, and Martin Donovan as Ralph. It is available on videocassette and DVD.

A made for television movie adaptation was directed by James Cellan Jones and broadcast in 1968. Starring Suzanne Neve as Isabel, James Maxwell as Gilbert, and Richard Chamberlain as Ralph, this movie is available on videocassette and DVD.

An abridged audiocassette recording of The Portrait of a Lady, with Gayle Hunnicutt as reader, was published by HighBridge in 1995. An unabridged version with Laural Merlington as reader was published by Brilliance Audio in 1998.

An unabridged version of The Portrait of a Lady, with Laural Merlington as reader, was published by Brilliance Audio in 1998.