The Old Man and the Sea was adapted as a feature film starring Spencer Tracy as Santiago and Felipe Pazos as The Boy, Warner Brothers, 1958. This film has been praised for some of its visual effects, and the score won an Academy Award.

It was also the source of a made-for-TV production in 1990 starring Anthony Quinn, Gary Cole, Alexis Cruz, Patricia Clarkson, and Francesco Quinn.

The novel is also available on a two-cassette sound recording narrated by Charlton Heston.