"The Lady, or the Tiger?" was adapted as a three-act operetta on May 7, 1888, in Wallack's Theatre, New York, with Stockton present in the opening-night audience. Another company in London opened the play that same night at the Elephant and Castle Theatre. Neither production lasted long, though the American version was revived for a short time during the 1890s.

. "The Lady, or the Tiger?" was adapted for film in 1970 by the Encyclopedia Britannica Educational Corporation. The story was set in the space-age, and a separate II-minute discussion of the story by Clifton Fadiman was produced at the same time. Both short films are distributed on videotape by Britannica Films.