A dramatization of Ethan Frome by Owen and Donald Davis was produced in New York in 1936.

A 1993 screen version directed by John Madden starred Liam Neeson as Ethan, Joan Allen as Zeena, and Patricia Arquette as Mattie. It was co-produced by American Playhouse, Companion Productions, and BBC Films and released by Miramax.

Richard Krausnick adapted and directed the novel as a full-length stage play for Shakespeare and Company, who first performed it in 1995 in Lenox, Massachusetts, where Wharton had a home.

An unabridged audio recording read by C. M. Herbert is available from Blackstone Audiobooks.