The Age of Innocence was adapted as a silent film by Olga Printzlau, produced in 1924 by Warner Brothers. In 1934, Margaret Ayer Barnes, Victor Heerman, and Sarah Y. Mason adapted the novel as a film in a production by RKO Radio Pictures, Inc. Most recently, in 1993, Martin Scorsese directed a Columbia Pictures adaptation of the novel by Scorsese and Jay Cocks. The film starred Daniel Day-Lewis as Newland Archer, Michelle Pfeiffer as Countess Olenska, and Winona Ryder as MayWelland.

A well-received stage adaptation was performed on Broadway in 1929.

Numerous audio adaptations have been made for listeners to enjoy the story on tape. These include releases by Books on Tape, 1982; Bantam Doubleday Dell Publishing Group, 1992; Bantam Books-Audio, and Random House, both 1993; Big Ben Audio, Blackstone Audio, Dove Entertainment (read by Joanne Woodward), and Penguin Audiobooks, all 1996; Bookcassette and Brilliance Corp., both 1997; and Audio Partners Publishing Corp., 1999.