Between 1922 and 1925, Lardner wrote 3,744 panels for a syndicated comic strip based on the characters of You Know Me Al (collected in 1979).

Several of his other sports stories were made into films: The New Klondike (1926), a silent film with a baseball theme by Lardner, directed by Lewis Milestone; Fast Company (1929), based on "Elmer the Great" by Lardner and George S. Kaufman (which, in turn, was based on Lardner's baseball story, "Hurry Kane"), directed by A. Edward Sutherland; Elmer the Great (1933), a remake of Fast Company, directed by Mervyn LeRoy and featuring Joe E. Brown; Alibi Ike (1935), based on Lardner's baseball story of the same title, and directed by Roy Enright, also featuring Joe E. Brown; Cowboy Quarterback (1939), another remake of Fast Company, shifting the sport to football, and directed by Noel Smith and featuring Harry Lynn; Champion (1949), based on Lardner's story of the same title, directed by Mark Robson...