As third in a series of four Rama novels, The Garden of Rama contains references to its main characters' actions in the prior Rama II (1989) and even some connections with Rendezvous with Rama.

Nicole des Jardins Wakefield continues the protagonist role in Rama Revealed (1994). Typically, most of the Clarke science fiction inventory employs one or more of the themes of human potential for learning, application of learning to improving life through technology, and the quest to explore and understand the vast universe beyond the limits of any Earthbound perspective.