Muscular Dystrophy - Research Article from Macmillan Science Library: Genetics

This encyclopedia article consists of approximately 6 pages of information about Muscular Dystrophy.
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Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder with a worldwide occurrence of one in four thousand newborn males, with approximately one-third of the cases arising from new mutations. DMD was named after the French neurologist Duchenne de Boulogne, who described the disorder in 1861. Becker muscular dystrophy (BMD), named after Peter Becker, a German geneticist who first described it in the mid-1950s, is a disorder that is very similar to DMD but has a much milder course. In 1983 these disorders were first shown to be located on the short arm of the X chromosome. The disorders are now known to be allelic, meaning an alternate form of the DMD gene causes BMD.

A cross-section of healthy muscle tissue. A cross-section of healthy muscle tissue.

Because DMD is X-linked, almost all cases occur in males. Boys with DMD are normal at birth, and their early motor milestones occur at normal...

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This section contains 1,552 words
(approx. 6 pages at 300 words per page)
Buy the Muscular Dystrophy Encyclopedia Article
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Macmillan Science Library: Genetics
Muscular Dystrophy from Macmillan Science Library: Genetics. Copyright © 2001-2006 by Macmillan Reference USA, an imprint of the Gale Group. All rights reserved.
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