Epistasis - Research Article from Macmillan Science Library: Genetics

This encyclopedia article consists of approximately 3 pages of information about Epistasis.
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Puzzling Inheritance Patterns Explained

There are many examples of epistasis. One of the first to be described in humans is the Bombay phenotype, involving the ABO blood group system. Individuals with this phenotype lack a protein called the H antigen (geno-type hh), which is used to form A and B antigens. Even though such individuals may have A or B genes, they appear to be blood group O because they lack the H antigen.

Another well-known example is coat color in mice. Two coat-color loci are involved. At locus A, color is dominant over albino (lack of pigment). At locus B, the coat color agouti is dominant over black. A mouse that is homozygous for the albino gene will show no pigment regardless of its genotype at the other locus. Thus the A and B loci are epistatic.

It is likely that the phenomenon of lack of penetrance, in...

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This section contains 753 words
(approx. 3 pages at 300 words per page)
Buy the Epistasis Encyclopedia Article
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Macmillan Science Library: Genetics
Epistasis from Macmillan Science Library: Genetics. Copyright © 2001-2006 by Macmillan Reference USA, an imprint of the Gale Group. All rights reserved.
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