Aids Research - Research Article from Macmillan Science Library: Space Sciences

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Structure-Based Drug Design

The three-dimensional structure of a protein is useful because it helps scientists understand the protein's function in biological systems. In addition, most known diseases are based on proteins that are not working properly within the human body or on foreign proteins that enter the body as part of harmful bacteria, viruses, or other pathogens. The three-dimensional structure of these disease-related proteins can aid scientists in designing new pharmaceutical agents (drugs) that specifically interact with the protein, thereby alleviating or lessening the harmful effects of the associated diseases.

This method of designing new and more effective pharmaceuticals, known as structure-based drug design, was used to develop many of the new-generation AIDS drugs. These drugs were developed using Earth-grown crystals. There are, however, a number of other protein targets in the HIV virus as well as in most other pathogens that have yet to be crystallized. Attempts...

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This section contains 702 words
(approx. 3 pages at 300 words per page)
Buy the Aids Research Encyclopedia Article
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Macmillan Science Library: Space Sciences
Aids Research from Macmillan Science Library: Space Sciences. Copyright © 2001-2006 by Macmillan Reference USA, an imprint of the Gale Group. All rights reserved.
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