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"The Universe in a Single Atom" by his Holiness the Dalai Lama is an exploration and comparison of the similarities and differences in the world of science and Buddhism. The Dalai Lama spent over 40 years studying with great scientific minds and he was trained in meditative, spiritual, and philosophical study of Buddhism.

In this book, using a first-person perspective, he addressed why it was important to pursue studies in spiritual realms as well as scientific realms in order to try to arrive at a complete picture of the truth. He felt that both science and religion had points in which they could help each other as long as each was kept in balance. The Dalai Lama cited parallels between scientific and contemplative examinations of reality.