Hunters of the Dusk is set in the real world with significant differences. In this enhanced world Vampires and Vampaneze exist, as do Little People, those beings created by Mr. Tiny. Although there are humans in this world and the same technology as the real earth the supernatural powers of Mr. Tiny, the Vampires, Evanna and Mr. Tall do not exist in the real world. No specific mention is made of exactly where in the real world Hunters of the Dusk takes place.