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An unknown menace is a recurring idea in the story. When the first known person died of the disease that would later become a crushing epidemic in Philadelphia in 1793, little attention was given to his passing. Even when people living in the same building with the man contracted the disease and died, there was no fear that a plague was on the city's horizon. But as doctors began to see an uptick in the number of patients who had markedly high fevers, coarse black vomit and a slight yellowing to their skin did they begin to realize that there was a budding epidemic. But no one in the medical field had any idea what it was!