Helstone - The main characters in "North and South" move from this place in Southern England to a northern town.
Milton - This is an industrial town in Northern England. The majority of the book is set here.
Harley Street, London - Margaret lived with her Aunt Shaw and cousin Edith here as a teenager. She goes back to this location when both her mother and father die.
Marlborough Street - Mr. Hale claims that this place is the foremost of its kind in Milton. Mr. Thornton's mill house is situated at the end of it.
The Mill House - Mr. Thornton and his mother and sister live in a cottage next door to this location. Workers break through its back gates to confront Mr. Thornton.
The Higgins House - This location, small and often cold, is where Margaret visits Bessy and later on Nicholas.
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