1519-1522—Conquest of Mexico
1521-1529—Turkish invasion of southern Europe
1522-1559—Hapsburg-Valois Wars
1524-1525—Peasants' War
1546-1547—Schmalkaldic War
1557-1582—Livonian War
1562-1598—French wars of religion
1585-1589—War of the Three Henries
- Alonso de Nebrija publishes his grammar of Spanish, the first grammar of any vernacular language in Europe. In his introduction he writes that "language is the companion of empire."
- 1 Jan.
Ferdinand and Isabella conquer the kingdom of Granada, ending eight hundred years of Muslim rule on the Iberian peninsula.
- 31 Mar.
The decree of expulsion is issued in Spain, requiring all Jews to leave or convert to Christianity within three months.
- 12 Oct.
After six weeks at sea Christopher Columbus makes landfall in the Caribbean.
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