Indian Journal of Human Genetics, July 1st, 2006
About 15% of couples attempting pregnancy have reduced infertility; and in approximately 40-50% of all cases, the reason is male-factor infertility.[1 ],[2 ] Contributing factors such as infection, varicocele, endocrine disorders, spermatic duct obstruction, antisperm antibodies, etc., are described as idiopathic male infertility, accounting for over 20% of all male-factor infertility cases. However, in 60% of cases, male infertility could be the result of genetic factors, including cytogenetic abnormalities and microdeletions of the Y chromosome.[2 ],[3 ] Tiepolo and Zuffardi[4 ] have postula...
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