The Journal of Nutrition, October 1st, 2006
Expanded Abstract
Xenobiotic metabolism-the double-edged sword
It has been two decades since Wattenberg's seminal review on the chemoprevention of cancer, cited over 900 times according to the ISI Web of Knowledge(SM), subdivided cancer inhibitory agents into 3 broad categories (1). The classification scheme included 1) inhibitors of carcinogen formation from precursors, 2) agents that alter xenobiotic metabolism and protect against DNA damage, so-called "blocking" agents, and 3) "suppressing" agents that act postinitiation to prevent initiated cells from progressing to neoplasia. The review...
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