The Scientist, May 1st, 2006
Histones serve as slates to a dizzying array of modifications, but researchers are confident they can decipher the epigenetic puzzle.
Roughly two meters of DNA gets packed into every cell nucleus in the human body. In addition to stuffing all that information into a sphere 3 to 10 microns across, the proteins that perform this task must also ensure that in each cell certain genes are constantly transcribed, while others lie ready, and other regions remain dormant, practically inaccessible. Within this cramped, chaotic space, an army of proteins must manage cellular information, decide cell fa...
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