The Scientist, January 27th, 2003
What is the histone code? Different chemical marks, such as acetylation, methylation, or phosphorylation, are made to numerous residues on the N-terminal tails of histone proteins. Some posit that they act as readable and specific landing pads for proteins that control chromatin modeling and transcriptional regulation. The marks appear to be clustered in different regulatory groups signifying "on" and "off" portions of the genome, and some of the proteins that make and read these marks seem to have properties that allow the patterns to spread and be passed on to new histones.
Since when was t...
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