Chemistry and Industry, July 18th, 1994
A cost effective and accurate way of synthesising natural compounds hinges on controlling the chirality of the products in question
Asymmetric transformations invariably involve the conversion of a two dimensional substrate into a three-dimensional product. For ketone reductions this is achieved by the overall addition of hydrogen to one face of the carbonyl group. In the case of the acetophenone reduction shown in Figure 1, addition to the back face gives 1-phenethyl alcohol with R-configuration, while addition from the front face gives the alcohol with S-configuration. The problem, of cou...
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