Mayo Clinic Proceedings, July 1st, 2002
The 1993 Nobel Prize in chemistry was awarded jointly to 2 biochemists, American Kary Banks Mullis and Canadian Michael Smith (1932- ). Mullis received the award for his invention of the polymerase chain reaction (PCR), a simple technique that allows a specific stretch of DNA to be copied billions of times in a few hours. Smith developed a procedure known as site-directed mutagenesis and applied it to the study of proteins. Smith's method allows researchers to reprogram the genetic code and, consequently, to construct proteins with new properties. The 2 methods have stimulated basic biochemica...
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