Military Medicine, February 1st, 2002
The analysis of chromosome translocations by fluorescence in situ hybridization ("whole chromosome painting") is the gold standard endpoint for radiation biological dosimetry. Translocation formation requires mis-repair of two or more DNA double-strand breaks, a critical class of damage that is efficiently induced by ionizing radiation in a dose-responsive manner. Translocations are widely used for radiation exposure assessment because they provide a sensitive detection system for low doses, show good specificity for radiation exposure, persist for decades, and are highly relevant to tumorigen...
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