The Journal of Nuclear Medicine, August 1st, 2007
Radiopharmaceuticals that can target the random metastatic dissemination of melanoma tumors may present opportunities for imaging and staging the disease as well as potential radiotherapeutic applications. A novel molecule, 2-(2-(4-(4-^sup 123^I-iodobenzyl)piperazin-1-yl)-2-oxoethyl)isoindoline-1-,3-dione-(MEL037), was synthesized, labeled with ^sup 123^I, and evaluated for application in melanoma tumor scintigraphy and radiotherapy. Methods: The tumor imaging potential of ^sup 123^I-MEL037 was studied in vivo in C57BL/6J female mice bearing the B16F0 murine melanoma tumor and in BALB/c nude m...
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