The Journal of Nuclear Medicine, August 1st, 2005
Because of the short path length in tissues (<100 µm) and the high linear energy transfer (~100 keV/µm), α-particle therapy offers the potential for specific tumor cell killing with a low level of damage to surrounding tissues (1). Clinical applications for which this approach is favorable include minimum residual tumor tissue (2,3) and local-regional administration settings (4) as well as targeting of tumor vasculature. Because of the geometry of tumor cell populations, radiation with short ranges in tissue should be desirable because a larger fraction of decay energy would be depos...
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