Photochemistry and Photobiology, October 1st, 2002
Photodynamic Inactivation of Isolated Crayfish Mechanoreceptor Neuron: Different Death Modes Under Different Photosensitizer Concentrations
ABSTRACT
To study the mechanism of photodynamic nerve cell killing, isolated crayfish mechanoreceptor neurons were photosensitized by the sulfonated aluminum ophthalocyanine Photosens. Neuron activity was continuously recorded until irreversible abolition. Intense (10-^sup 5^ M Photosens) or weak (10-^sup 7^ M Photosens) photosensitization induced different bioelectric neuron responses: firing activation followed by irreversible depolarization block or g...
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