Clinical Chemistry, February 1st, 2007
To the Editor:
Sample handling requirements for uric acid analysis during recombinant uric acid oxidase (rasburicase, Sanofi-Synthelabo) therapy are a matter of concern. Rasburicase catalyzes the oxidation of uric acid to allantoin, which is easily excreted by the kidney. It is indicated for the treatment and prophylaxis of malignancy- or chemotherapy-associated hyperuricemia (1).
For monitoring uricemia in patients receiving rasburicase therapy, the manufacturer recommends keeping blood samples in ice water immediately after collection and during specimen transport until analysis. When samp...
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