Genetics, February 1st, 2006
WHEN I started my laboratory at Caltech in 1987, hung on my door a wall chart from Oncogene Sciences with all the known proto-oncogenes and their cellular locations and regulatory relationships. One of these, ras, was identified by viral and cancer genetics as a dominant oncogene in many tumors and in transforming retroviruses. The RAS protein is a small GTPase, which undergoes a cycle of guanine nucleotide exchange and hydrolysis. RAS was known to be active when bound to GTP, but its normal role in the cell was not known, nor was how it became activated and what it did once it was. RAS and ep...
HighBeam Research, Free Preview: 'Pathway to RAS'... Full Membership required for unlimited access. Free 7-day trial.
Subscribers: HighBeam content is only available to HighBeam subscribers. Click the link above for more information.
