Drug Topics, May 20th, 2002
Generic name
Fondaparinux
Proprietary name/manufacturer
Arixtra/Organon-Sanofi-Synthelabo
FDA-approved indication
For the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism, in patients undergoing hip fracture surgery, hip replacement surgery, or knee replacement surgery
Pharmacology
Fondaparinux, a synthetic pentasaccharide, acts as a selective, indirect inhibitor of factor Xa. The compound represents the minimal binding sequence of heparin required for binding to antithrombin III and binds exclusively to antithrombin III, producing a conformational change ...
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