The Scientist, December 5th, 2005
Though commercial transposon kits are designed for use in vitro or in prokaryotic cells, researchers also have historically used jumping genes to mutagenize and introduce genes in Drosophila and other model invertebrates. Transposon systems that work effectively in mammals are a relatively recent development, however.
Discovery Cenomics (www.discoverygenomics.com), based in Minneapolis, is using one such system, called Sleeping Beauty, to develop gene therapy approaches for human use, according to chief science officer Perry Hackett. Sleeping Beauty is also useful for inducing mutations in ma...
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